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Vladimir Spiegelman, M.D., Ph.D.

Vladimir Spiegelman, M.D., Ph.D.

Panhellenic Dance Marathon Endowed Chair in Pediatric Oncology; Professor, Pediatrics

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Vladimir Spiegelman, M.D., Ph.D.

Panhellenic Dance Marathon Endowed Chair in Pediatric Oncology; Professor, Pediatrics

Penn State College of Medicine

500 University Drive
Hershey, PA 17033

Email: vspiegelman@pennstatehealth.psu.edu

 

“Four Diamonds allows us to pursue avenues that otherwise wouldn’t be funded—more risky approaches that the federal government or other agencies will not fund until there’s a substantial amount of preliminary data to support it. Four Diamonds is absolutely instrumental for testing novel ideas.”

 

MILESTONES

Grants Funded

NIH NIAMS RO1 AR063361
"RNA-binding protein CRD-BP in melanocyte biology"
$250,000
Spiegelman, V. (PI)   
2013-2018 

NIH NCI R21 CA191550 
"CRD-BP-mediated regulation of Wnt signaling in intestinal tumorigenesis"
$150,000
Spiegelman, V. (PI)
2015-2018

PA Tobacco Settlement Fund
Precision Medicine for Melanoma Treatment
4100072562  
Spiegelman, V. (Co-I)
$187,500
2016-2017

Dermatology Foundation
"Achilles' heel in Melanoma - CRD-BP as a Potential Prognostic Marker and Therapeutic Target"
Career Development Award   Xu, Y. (PI)   
Spiegelman, V. (mentor)  
$50,000
2014-2017

 

CURRENT RESEARCH

 Dr. Spiegelman’s research focuses on the understanding of molecular pathways and environmental factors that lead to development of human malignancies, and employment of newly acquired knowledge for eradication of cancer. His research focuses on the mechanisms that govern the turnover of short-lived mRNAs that encode important regulators of cell proliferation, death and differentiation and the implications of this turnover for tumor development. The mechanisms regulating mRNA degradation, its alterations in human cancers and its potential ability of therapeutic modality are of primary interest.

 

SELECTED PUBLICATIONS

The following are publications of Dr. Spiegelman’s lab:

Craig E. and Spiegelman V. S. Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents. Pigment Cell Melanoma Res. Jan;25(1):83-7, 2012.
Schmit T.L., Nihal M., Ndiaye M.A., Setaluri V., Spiegelman V.S. and Ahmad N. Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis. Cancer Research. 72(15):3864-72, 2012.

Craig E.A., Weber J.D. and Spiegelman V. S. Involvement of the mRNA binding protein CRD-BP in the regulation of metastatic melanoma cell proliferation and invasion by hypoxia. Journal of Cell Science. 125(Pt 24):5950-4, 2012.

Tarapore R.S., Siddiqui I.A., Adhami V.M., Spiegelman V.S., Mukhtar H. The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling, Molecular Nutrition & Food Research, 57(11):1950-8, 2013.

Hamilton K.E., Noubissi F.K., Katti P.S.,. Hahn C.M, Davey S.R., Lundsmith E.T., Klein-Szanto A.J., Rhim A.D., Spiegelman V.S., Rustgi A.K. IMP1 promotes tumor growth, dissemination, and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis 34(11):2647-54, 2013.

Wood, G. S. , Gunkel, J., Spiegelman, V.S., Snow, S., Vanness, E., Teng, J.M., and Xu Y. Non-melanoma skin cancer. In: Abeloff’s Clinical Oncology. Fifth edition. ELSEVIER, 2014.

Athar M., Li C., Kim A.L., Spiegelman V.S., Bickers D.R.  Sonic Hedgehog signaling in Basal Cell Nevus Syndrome. Cancer Research, 2014; 74(18):4967-752014.

Noubissi F. K., Kim T-W., Kawahara T., Longley B. J., Aughenbaugh  W.D., Berg E., Athar M., and Spiegelman V. S. Role of CRD-BP in the growth of human basal cell carcinoma cells. Journal of Investigative Dermatology, 2014, 134(6):1718-24.

Wu J., Salva K, Stutz N., Longley, B. J., Spiegelman, V.S., and Wood, G. S.  Quantitative Gene Analysis of Methylation and Expression (Q-GAME) in Fresh or Fixed Cells and Tissues, Exp. Dermatology, 2014, 23(5):304-9

Poenitzsch-Strong A.M., Setaluri V., and Spiegelman, V.S. microRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma. Arch Biochem Biophys, 2014, 563:118-24, 563:118-24.

Goswami S., Tarapore R. S., Poenitzsch-Strong A.M., TeSlaa J. J., Grinblat Y., Setaluri V., and Spiegelman, V.S. MicroRNA-340-Mediated Degradation of Microphthalmia-Associated Transcription Factor (MITF) mRNA is Inhibited by Coding Region Determinant Binding Protein (CRD-BP). J Biol Chem. 2015; 290(1):384-95.

Fakhraldeen S.A., Clark R.J., Roopra A., Chin E.N., Huang W., Castorino J., Wisinski K.B., Kim T., Spiegelman V.S., and Alexander C.M. Two isoforms of the RNA binding protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), are expressed in breast epithelium, and support clonogenic growth of breast tumor cells. J Biol Chem. 2015; 290(21):13386-400.

Hamilton K.E., Chatterji P., Lundsmith E.T., Andres S.F., Giroux V., Hicks P.D., Noubissi F.K., Spiegelman V.S.,  and Rustgi AK. Loss of Stromal Imp1 Promotes a Tumorigenic Microenvironment in the Colon. Mol Cancer Res. 2015; 13(11):1478-86.

Kim T-W., Havighurst T., Kim KM., Hebbring  S.J., Ye Z., Aylward J., Keles S., Xu Y.G., and Spiegelman V. S. RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma. Journal of Investigative Dermatology, 2017; 137(3):772-775.

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